Chemical composition and anti-proliferative activity of essential oils from some medicinal plants from Cachicadán, Región La Libertad, Perú.

This study evaluated the chemical composition and anti-proliferative activity of essential oils (EOs) obtained by hydrodistillation from seven medicinal plants from Cachicadán, La Libertad Región, Perú. Limonene (0.64 to 44.43%) and linalool (0.36 to 2.12%) were identified in all EOs by gas chromatography coupled to mass spectrometry analysis. The major components (relative intensity ≥ 10%) were cis-dihydro carvone, carvone, and cis-piperitone epoxide for Minthostachys mollis leaves; ß-pinene, limonene, and ledol for Lepechinia heteromorpha leaves; limonene, neral, and geranial for Aloysia citriodora, both leaves and flowers; α-pinene, and limonene for Myrcianthes myrsinoides leaves; and α-pinene, ß-myrcene, and (E)-ß-Ocimene for Dalea carthagenensis leaves. Constituted by (Z)-ß-ocimene, dihydrotagetone, (Z)-tagetone, and car-3-en-2-one, EO of Tagetes minuta leaves induced an irreversible cytostatic effect against MCF-7 human breast tumor cells. Further in vivo studies must be carried out to establish the safe and efficient dose of T. minuta EO as adjuvant treatment in oncological therapies.

Detection of changes in literary writing style using N-grams as style markers and supervised machine learning.

The analysis of an author's writing style implies the characterization and identification of the style in terms of a set of features commonly called linguistic features. The analysis can be extrinsic, where the style of an author can be compared with other authors, or intrinsic, where the style of an author is identified through different stages of his life. Intrinsic analysis has been used, for example, to detect mental illness and the effects of aging. A key element of the analysis is the style markers used to model the author's writing patterns. The style markers should handle diachronic changes and be thematic independent. One of the most commonly used style marker in extrinsic style analysis is n-gram. In this paper, we present the evaluation of traditional n-grams (words and characters) and dependency tree syntactic n-grams to solve the task of detecting changes in writing style over time. Our corpus consisted of novels by eleven English-speaking authors. The novels of each author were organized chronologically from the oldest to the most recent work according to the date of publication. Subsequently, two stages were defined: initial and final. In each stage three novels were assigned, novels of the initial stage corresponded to the oldest and those at the final stage to the most recent novels. To analyze changes in the writing style, novels were characterized by using four types of n-grams: characters, words, Part-Of-Speech (POS) tags and syntactic relations n-grams. Experiments were performed with a Logistic Regression classifier. Dimension reduction techniques such as Principal Component Analysis (PCA) and Latent Semantic Analysis (LSA) algorithms were evaluated. The results obtained with the different n-grams indicated that all authors presented significant changes in writing style over time. In addition, representations using n-grams of syntactic relations have achieved competitive results among different authors.

Streamlining breast cancer and colorectal cancer biosimilar regulations to improve treatment access in Latin America: an expert panel perspective.

In a multiday conference, a panel of Latin American experts in biological cancer therapies and health economics were provided with questions to address the barriers restricting access to biosimilars in Latin America, specifically for patients with breast cancer and colorectal cancer, for whom biosimilars can be a path forward to increasing access to care. During the conference, responses were discussed and edited until a consensus was achieved. The regulatory challenges identified in the conference included heterogenous regulations, non-adherence to regulatory pathways, scarcity of market opportunity, inadequate naming of biosimilars by only using international non-proprietary names, imprecise use of interchangeability and substitution, and insufficient traceability and pharmacovigilance. Recommendations were developed to improve the implementation of regulatory pathways and reliable procurement strategies that increase access to these therapies with adequate traceability and outcome measures; efforts from all involved stakeholders will be crucial. These recommendations can serve as a strategy for biosimilar adoption in other countries in a similar situation.

A Systematic Review for Cognitive State-Based QoE/UX Evaluation.

Traditional evaluation of user experience is subjective by nature, for what is sought is to use data from physiological and behavioral sensors to interpret the relationship that the user's cognitive states have with the elements of a graphical interface and interaction mechanisms. This study presents the systematic review that was developed to determine the cognitive states that are being investigated in the context of Quality of Experience (QoE)/User Experience (UX) evaluation, as well as the signals and characteristics obtained, machine learning models used, evaluation architectures proposed, and the results achieved. Twenty-nine papers published in 2014-2019 were selected from eight online sources of information, of which 24% were related to the classification of cognitive states, 17% described evaluation architectures, and 41% presented correlations between different signals, cognitive states, and QoE/UX metrics, among others. The amount of identified studies was low in comparison with cognitive state research in other contexts, such as driving or other critical activities; however, this provides a starting point to analyze and interpret states such as mental workload, confusion, and mental stress from various human signals and propose more robust QoE/UX evaluation architectures.

Platinum ineligibility in squamous cell carcinoma of the head and neck: consensus from Central America and the Caribbean.

The high incidence of head and neck cancer in Central America and the Caribbean, together with limitations in the healthcare system for patients with locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) in this region necessitate a consensus of opinion based on a review of the literature on therapy with cisplatin plus radiation. Such an approach will ensure appropriate selection of patients who can benefit from therapy and reduce the incidence of related adverse events. Therefore, we recorded the opinion of experts in the region in order to identify needs and challenges in the treatment of LA SCCHN.

Salud alimentaria y medidas de prevención de las enfermedades crónico degenerativas, en la población de Tultepec, Estado de México, y su aplicación con el organon de la medicina / Food safety and prevention of chronic degenerative diseases, in the town of Tultepec, State of Mexico, and its application with the Organon of Medicine

La relación de los hábitos alimentarios con la salud y la enfermedad ha preocupado al hombre desde sus orígenes. El Organon de la medicina contiene los principios de la terapéutica homeopática, a manera de integrar, estudiar y conocer todo cuanto le afecta al enfermo tanto de su interior como de su medio para proveerle de la salud, con el objetivo de conservar la vida. El presente trabajo busca conocer la percepción de la población del municipio de Tultepec (Estado de México) sobre salud alimentaria y medidas de prevenciónde las enfermedades crónico-degenerativas. Se realizó un estudio de tipo exploratorio, y la muestra fue de n=80. Se aplicó una encuesta para conocer los hábitos dietéticos y los tipos de alimentos que se consumen frecuentemente, la ingesta de agua al día, el tipo de actividad física y los factores predisponentes parapadecer sobrepeso y obesidad, así como su relación con enfermedades crónicodegenerativas. Los resultados muestran que la población no tiene un concepto generalizado sobre salud alimentaria; las ideas son múltiples, dejando ver que existe un gran analfabetismo sobre hábitos alimentarios. Surge entonces la necesidad de poner límites, promover la actividad física, estimular pautas y conductas adecuadas para preservar la salud, basadas en el parágrafo 261 del Organon que dice que, tratándose de enfermedades crónicas, el régimen más apropiado consiste en eliminar todo lo que obstruya la recuperación, moral sin malicia, recreación intelectual, ejercicio activo al aire libre, alimentación y bebidas apropiadas y nutritivas.

The relationship of dietary health and disease has concerned man since its inception. The Organon of medicine contains the principles of homeopathic therapy, a way to integrate, explore and learn everything that affects the patient will both its interior and its environment to provide health, which aims to preserve life. The present study aims to determine the population perception of the health prevention of chronic degenerative diseases in the Tultepec municipality (Estado de Mexico). We conducted an exploratory study, the sample consisted of n=80, we applied a survey to assess the dietary habits and types of food consumed frequently, daily water intake, physical activity, and predisposing factors overweight and obesity and its relation to chronic degenerative diseases. The results show that the population does not have a generalized concept of health food, multiple ideas are revealing that there is great illiteracy on eating habits. This raises the need to set limits, promote physical activity, encourage appropriate behavior patterns and to preserve the health, based on paragraph 261 of the Organon it says, in the case of chronic diseases, the most appropriateregime is to remove everything that obstructs the recovery, without malice moral, intellectual recreation, active exercise outdoors, food and drink appropriate and nutritious.

Salud alimentaria y medidas de prevención de las enfermedades crónico degenerativas, en la población de Tultepec, Estado de México, y su aplicación con el Organon de la Medicina / Food safety and prevention of chronic degenerative diseases, in the town of Tultepec, State of Mexico, and its application with the Organon of Medicine

La relación de los hábitos alimentarios con la salud y la enfermedad ha preocupado al hombre desde sus orígenes. El Organon de la medicina contiene los principios de la terapéutica homeopática, a manera de integrar, estudiar y conocer todo cuanto le afecta al enfermo tanto de su interior como de su medio para proveerle de la salud, con el objetivo de conservar la vida. El presente trabajo busca conocer la percepción de la población del municipio de Tultepec (Estado de México) sobre salud alimentaria y medidas de prevenciónde las enfermedades crónico-degenerativas. Se realizó un estudio de tipo exploratorio, y la muestra fue de n=80. Se aplicó una encuesta para conocer los hábitos dietéticos y los tipos de alimentos que se consumen frecuentemente, la ingesta de agua al día, el tipo de actividad física y los factores predisponentes parapadecer sobrepeso y obesidad, así como su relación con enfermedades crónicodegenerativas. Los resultados muestran que la población no tiene un concepto generalizado sobre salud alimentaria; las ideas son múltiples, dejando ver que existe un gran analfabetismo sobre hábitos alimentarios. Surge entonces la necesidad de poner límites, promover la actividad física, estimular pautas y conductas adecuadas para preservar la salud, basadas en el parágrafo 261 del Organon que dice que, tratándose de enfermedades crónicas, el régimen más apropiado consiste en eliminar todo lo que obstruya la recuperación, moral sin malicia, recreación intelectual, ejercicio activo al aire libre, alimentación y bebidas apropiadas y nutritivas. (AU)

The relationship of dietary health and disease has concerned man since its inception. The Organon of medicine contains the principles of homeopathic therapy, a way to integrate, explore and learn everything that affects the patient will both its interior and its environment to provide health, which aims to preserve life. The present study aims to determine the population perception of the health prevention of chronic degenerative diseases in the Tultepec municipality (Estado de Mexico). We conducted an exploratory study, the sample consisted of n=80, we applied a survey to assess the dietary habits and types of food consumed frequently, daily water intake, physical activity, and predisposing factors overweight and obesity and its relation to chronic degenerative diseases. The results show that the population does not have a generalized concept of health food, multiple ideas are revealing that there is great illiteracy on eating habits. This raises the need to set limits, promote physical activity, encourage appropriate behavior patterns and to preserve the health, based on paragraph 261 of the Organon it says, in the case of chronic diseases, the most appropriateregime is to remove everything that obstructs the recovery, without malice moral, intellectual recreation, active exercise outdoors, food and drink appropriate and nutritious. (AU)

Heterologous expression of manganese peroxidase in Aspergillus niger and its effect on phenanthrene removal from soil.

A strain of Aspergillus niger, previously isolated from sugarcane bagasse because of its capacity to degrade phenanthrene in soil by solid culture, was used to express a manganese peroxidase gene (mnp1) from Phanerochaete chrysosporium, aiming at increasing its polycyclic aromatic hydrocarbons degradation capacity. Transformants were selected based on their resistance to hygromycin B and the discoloration induced on Poly R-478 dye by the peroxidase activity. The recombinant A. niger SBC2-T3 strain developed MnP activity and was able to remove 95% of the initial phenanthrene (400 ppm) from a microcosm soil system after 17 days, whereas the wild strain removed 72% under the same conditions. Transformation success was confirmed by PCR amplification using gene-specific primers, and a single fragment (1,348 bp long, as expected) of the recombinant mnp1 was amplified in the DNA from transformants, which was absent from the parental strain.

[Clinical guidelines for detection, prevention, diagnosis and treatment of systemic arterial hypertension in Mexico (2008)]. / Guías clínicas para la detección, prevención, diagnóstico y tratamiento de hipertensión arterial sistémica en México (2008).

The multidisciplinary Institutional Committee of experts in Systemic Arterial Hypertension from the National Institute of Cardiology "Ignacio Chávez" presents its update (2008) of "Guidelines and Recommendations" for the early detection, control, treatment and prevention of Hypertension. The boarding tries to be simple and realistic for all that physicians whom have to face the hypertensive population in their clinical practice. The information is based in the most recent scientific evidence. These guides are principally directed to hypertensive population of emergent countries like Mexico. It is emphasized preventive health measures, the importance of the no pharmacological actions, such as good nutrition, exercise and changes in life style, (which ideally it must begin from very early ages). "We suggest that the changes in the style of life must be vigorous, continuous and systematized, with a real reinforcing by part of all the organisms related to the health education for all population (federal and private social organisms). It is the most important way to confront and prevent this pandemic of chronic diseases". In this new edition the authors amplifies the information and importance on the matter. The preventive cardiology must contribute in multidisciplinary entailment. Based mainly on national data and the international scientific publications, we developed our own system of classification and risk stratification for the carrying people with hypertension, Called HTM (Arterial Hypertension in Mexico) index. Its principal of purpose this index is to keep in mind that the current approach of hypertension must be always multidisciplinary. The institutional committee of experts reviewed with rigorous methodology under the principles of the evidence-based medicine, both, national and international medical literature, with the purpose of adapting the concepts and guidelines for a better control and treatment of hypertension in Mexico. This work group recognizes that hypertension is not an isolated disease; therefore its approach must be in the context of the prevalence and interaction with other cardiovascular risk factors such as obesity, diabetes, dislipidemia and smoking among others. The urgent necessity is emphasized to approach in a concatenated form the diverse cardiovascular risk factors, since independently of which they share common pathophysiological mechanisms, its suitable identification and control will affect without any doubt the natural history of the other concatenated risk factor. By all means that to greater participation of factors, greater it will be the global cardiovascular risk but never, however, the specific weight is due to avoid that each one has on the global cardiovascular risk. In this Second edition we try to amplify and give systematic forms for the clinical approach for the suspicion of secondary hypertension and we emphasizes that hypertension in the woman with or without menopause should be careful analyzed, and special recommendations are given for the hypertension in pregnancy. Also we have approached some aspects related to the hypertensive emergencies and other special situations. In this second version some recommendations are presented for boarding hypertension in children and adolescents.

Guías clínicas para la detección, prevención, diagnóstico y tratamiento de hipertensión arterial sistémica en México (2008) / Clinical guidelines for detection, prevention, diagnosis and treatment of systemic arterial hypertension in Mexico (2008)

The multidisciplinary Institutional Committee of experts in Systemic Arterial Hypertension from the National Institute of Cardiology [quot ]Ignacio Chávez[quot ] presents its update (2008) of [quot ]Guidelines and Recommendations[quot ] for the early detection, control, treatment and prevention of Hypertension. The boarding tries to be simple and realistic for all that physicians whom have to face the hypertensive population in their clinical practice. The information is based in the most recent scientific evidence. These guides are principally directed to hypertensive population of emergent countries like Mexico. It is emphasized preventive health measures, the importance of the no pharmacological actions, such as good nutrition, exercise and changes in life style, (which ideally it must begin from very early ages). [quot ]We suggest that the changes in the style of life must be vigorous, continuous and systematized, with a real reinforcing by part of all the organisms related to the health education for all population (federal and private social organisms). It is the most important way to confront and prevent this pandemic of chronic diseases[quot ]. In this new edition the authors amplifies the information and importance on the matter. The preventive cardiology must contribute in multidisciplinary entailment. Based mainly on national data and the international scientific publications, we developed our own system of classification and risk stratification for the carrying people with hypertension, Called HTM (Arterial Hypertension in Mexico) index. Its principal of purpose this index is to keep in mind that the current approach of hypertension must be always multidisciplinary. The institutional committee of experts reviewed with rigorous methodology under the principles of the evidence-based medicine, both, national and international medical literature, with the purpose of adapting the concepts and guidelines for a better control and treatment of hypertension in Mexico. This work group recognizes that hypertension is not an isolated disease; therefore its approach must be in the context of the prevalence and interaction with other cardiovascular risk factors such as obesity, diabetes, dislipidemia and smoking among others. The urgent necessity is emphasized to approach in a concatenated form the diverse cardiovascular risk factors, since independently of which they share common pathophysiological mechanisms, its suitable identification and cont

Características clínicas de la meningitis por Criptococo en pacientes con VIH del Hospital Roosevelt durante el período de enero de 2001 a junio de 2002 / clinical characteristics of Cryptococcal meningitis in HIV infected patients, January 2001 to June 2002

El objetivo del presente estudio es establecer las características clínicas que comparten los pacientes con infección por VIH con diagnóstico de meningitis por criptococo. Dicho estudio se realizó durante el período de enero del 2001 a junio del 2002, se eligieron a 30 pacientes ingresados en el Hospital Roosevelt con diagnóstico de VIH con cultivo positivo para Cryptococcus neoformans. El 93/100 de los pacientes estudiados presentó como síntoma principal la cefalea, el signo clínico de papiledema encontrado en el 86/100, se observaron gran cantidad de pacientes con signos meningeos positivos (73/100), los pacientes en un porcentaje alto (40/100) presentaron alteración del estado de conciencia secundario...